The Cyprus Protocol – Multimodal Combination Therapy for Long COVID, Post-Vac and Chronic Illnesses

In the field of HIV and cancer, combination therapy is one of the most successful forms of treatment – often it is the gold standard in the specific field. 

En collaboration avec des contributeurs du monde entier et grâce à notre expérience clinique combinée à des recherches menées par des patients, nous avons mis au point le premier protocole de thérapie combinée multimodale pour le COVID long, le syndrome post-vacances et les maladies chroniques.

 We named it after it’s place of origin: 

Le protocole de Chypre

Below you find a dynamic list of the protocol’s elements and a treatment schedule example.

Les pathologies que nous traitons

Quelles sont les pathologies traitées au Centre d'aphérèse avec le Protocole de Chypre ?

Voici quelques exemples (non exhaustifs) des affections les plus courantes que nous traitons dans notre clinique :

  • Long Covid (PCS)
  • Post-Vac (PVS)
  • Syndromes post-infectieux / post-viraux
  • POTS
  • EDS
  • MCAS / IBS / SIBO
  • PANS / PANDAS
  • PIMS / MIS-C
  • Maladies auto-immunes
  • Sydrome de fatigue chronique
  • Affections réactivées (EBV, Mono, CMV, Herpès, Babesia, Bartonella)
  • Maladie de Lyme
  • Fibromyalgie
  • EM/SFC
  • Sclérose en plaques
  • Lupus
  • Arthrite rhumatoïde
  • Syndrome de Sjögrens
  • Raynaud’s Disease
  • Sclérodermie
  • Alzheimer
  • Parkinson
  • SFN / Neuropathie
  • MCS
  • Autres affections présentant des problèmes inflammatoires, auto-immuns et de microcirculation, ainsi que des affections causées par des toxines ou des agents pathogènes. 

Les éléments du protocole de Chypre

Cliquez sur chaque élément du protocole de Chypre pour plus de détails.

Pour chaque patient, le protocole doit être personnalisé.

With the new diagnostic tools of our D-T-R model – Continous Diagnostics we are now able to apply targeted treatments with higher precision. 

Supervision de la nutrition clinique

Independent of the treatment a patient is undergoing – without adapted nutrition for the three treatment phases pre-treatment, on-treatment and post-treatment, the achievable results differ.
This is why we base our Combination Therapy on individual and personalized nutrition plans for every patient, based on the results of blood panel test and food intolerance test that show IgG reactions to 287 foods (vegetables, fish & seafood, fruits, spices, nuts, legumes, meat, egg & milk, cereals & seeds, nuts, coffee & tea and novel foods). 
Our Clinical Nutritionist Chryso Zorbas will hold your hand nutritionally from day one and guide you along the therapy with a personalized diet plan that will enhance your recovery process. Needless to say that our Health Coaching (see below) is a perfect match and goes hand in hand with our Clinical Nutrition Supervision.
Learn more about Clinical Nutrition Supervision here

Coaching santé

Chronic Illness is very complex – having an expert patient turned professional Health Coach by your side throughout your whole journey offers priceless knowlege and guidance.
Our Health Coach Tanja Walser will coach you from day one and guide you along the therapy with a personalized coaching plan that will include all the dos and don’ts and give you a headstart despite brainfog, anxiety or other symptoms you are battling with.
Learn more about Health Coaching here

Aphérèse H.E.L.P. , Inusphérèse® et Immunoadsorption

Our most effective treatments to date: At the core of our multimodal Combination Therapy are several forms of Therapeutic Apheresis’ – special blood purifications by precipitation/adsorption/filtration procedures. They serve to treat microcirculation / blood flow issues (microclots are removed, blood flow increased) and removes pathogenic or disease-sustaining proteins as well as protein-bound substances and autoantibodies from the blood. Amongst other substances environmental toxins, inflammation proteins, viral spike protein, cholesterol + autoantibodies are removed

Learn more about H.E.L.P. Apheresis 
Learn more about Inuspheresis®  
Learn more about Immunoadsorption 
In some cases H.E.L.P. Apheresis will be combined with TPPE – Therapeutic Partial Plasma Exchange 

Hyperthermie du corps entier

Le système d'hyperthermie du corps entier Heckel HT3000 permet une augmentation ciblée de la température centrale du corps, allant d'une fièvre légère à une forte fièvre. L'hyperthermie du corps entier ne s'attaque pas seulement aux symptômes, mais vise également à rétablir un meilleur contrôle de la régulation dans l'ensemble de l'organisme. Les systèmes d'hyperthermie du corps entier de Heckel contribuent de manière significative au traitement d'un large éventail de maladies et d'affections, allant de la promotion de la santé au soulagement de la douleur et au traitement de soutien des affections chroniques et du cancer. Dans Long Covid et Post Vac, la libération des récepteurs et l'élimination des protéines pathogènes sont d'autres effets recherchés.

IV Therapy – Intravenous Treatments (including Peptides and Chelation Agents)

Long Covid and many other Chronic Illnesses are at their root an endothelitis/vasculitis with severe inflammation, combined with hypercoagulation and often viral persistence. Autoimmunity components can be involved too. 
IV treatments work directly where needed the most: in the blood vessels in the desired concentration.

IV/Intravenous therapies that are used in our Long COVID and Chronic Illnesses Combination Therapy are:

– IV Vitamin C (Reducing inflammation)
– IV Glutathione (Antioxidant)
– IV Multivitamin Protocol (Balancing deficiencies)
– IV NAD+ (Metabolism/mitochondria benefits)
– IV Alpha Lipoic Acid (Metabolism/nerve pain reduction)
– IV Zinc (Reducing inflammation, speeding up recovery)
– IV Magnesium (Electrolyte reducing fatigue and anxiety)
– IV NAC (Reduces brainfog/relieves respiratory discomfort)
– IV Taurin (Is Cytoprotective (cell protective) and detoxyfying)
– IV Arginine (Increases elasticity of blood vessels and increases blood flow)
– IV Lysine (Increases cell healing and wound healing)
– Other IVs: Iron, Selenium, Amino Acids, Minerals and more

Peptide Therapy:

Peptide therapy offers a groundbreaking approach to restoring  balance and vitality for individuals struggling with long COVID,  post-vaccine syndrome, and chronic illnesses. Peptides are short chains  of amino acids that act as signaling molecules in the body, promoting  tissue repair, immune modulation, and cellular rejuvenation. By  targeting underlying dysfunctions such as inflammation, impaired  immunity, and mitochondrial damage, peptide therapy can accelerate  recovery, enhance energy, and support overall wellness. Tailored to each  patient’s unique needs, this therapy provides a safe and effective way  to improve quality of life, fostering the body’s natural ability to heal  and thrive.  

Find more information on our IV Therapy and Peptide Therapy click here for iv therapy and peptide therapy

Chelation Therapy:

Chelation therapy is a medical intervention characterized by the administration of chelating agents, substances with a high affinity for certain metal ions, to facilitate the removal of heavy metals and minerals from the body. 

Find more information on Chelation Therapy here

Thérapie nutraceutique

Our Nutraceutical treatment strategy for the detoxification from viral spike protein involves the following 4-step process:

The first step is preventing reinfection by blocking the receptors  on host cells, which the virus and viral spike protein use to gain  entry. 
The second step is to help restore autophagy processes, which are  the body’s natural way of cleaning out damaged cells and regenerating  new ones. 
The third step aids in liberating viruses and viral spike proteins by selectively targeting infected or transfected cells. 
The fourth step facilitates the sequestration of viral spike  protein and virus, effectively removing them. The most efficient way to  do this is H.E.L.P. Apheresis and where that is not possible, the use of  Algerol is indicated.

This  comprehensive approach aims to remove the spike protein from the body  safely while also enhancing the immune system’s ability to prevent  further infections.

At the end of our therapy course we add a 3-6 months NAC Augmented protocol.

Find more about Nutraceutical Therapy here

Protocoles de médication (antiviraux / anticoagulation et autres)

Medication and supplement protocols increase H.E.L.P. Apheresis results further and can be used to treat patients symptom-specific. The protocols include Antiviral Protocols and Anticoagulation Protocols.

Symptoms the medication protocols focus on are:

– Viral persistence
– Persisting hyper coagulation
– MCAS (mastcell activation syndrome), often combined with gastroparesis
– Endothelial damage, often combined with hypercholesterolaemia 
– Neuro inflammation/brain inflammation
– Fatigue, PEM often combined with mitochondrial dysfunction
– Insomnia 
– Induced anxiety/paranoia/depression 
– Reactivated viruses
– Others

Find more information on Antiviral Therapy and Anticoagulation Therapy

Thérapie de la douleur et de l'anxiété

Anxiety, Depression, PTSD, Chronic Pain and Fatigue Therapy for Long Covid and Chronic Illness
Are you or a loved one struggling with the lingering effects of Long Covid or battling the relentless challenges of chronic illness? At the Apheresis Center we understand the toll these conditions can take on both your physical and mental well-being. That’s why we offer revolutionary approaches to treatment.

Find more about Depression & Anxiety Therapy here

Hydrothérapie du côlon et traitement du syndrome MCAS

Colon Hydrotherapy, also known as colonic irrigation, constitutes an internal cleansing procedure designed to rid the colon of deleterious waste materials. This therapeutic intervention serves as a rapid and highly efficient means of detoxification for the body. The mild internal hydration expeditiously eliminates pathogenic toxins by leveraging the natural peristaltic movements, further facilitated by abdominal massage. Notably, this process has implications for individuals with symptoms that present similar to Mast Cell Activation Syndrome (MCAS), as it influence the systemic responses associated with this symptoms often triggered by Long Covid, Post Vac or other Chronic Illnesses.

Our Medical Team has designed a MCAS treatment package which is tailored to each patient individually

MCAS Blood Test (CCL2, IL-6, IL-8, IL-31, IL-33, TNF-alpha, Tryptase)
Nutrition Plan
3x Colon Hydrotherapy, ozonated treatment
3x Leaky Gut IV (L-Lysin, Taurin, L-Alanyl-Glutamin, Glycin, Cholinchlorid, Magnesiumchlorid, Kaliumchlorid 
MCAS Medication Plan including Nutraceuticals and Nanozeolites 

Find more information on Colon Hydrotherapy and MCAS Treatment here

Traitement par IgIV et mABs

The application of Intravenous Immunoglobulin (IVIG, if subcutaneously administered also called SCIG)) and monoclonal antibodies (mABs) like Evusheld or Xevudy (Sotrovimab) represents a new area in treating Long Covid, Post Vac and Chronic Illnesses. These conditions involve complex immune dysregulation and inflammatory responses. IVIG is a concentrated preparation of immunoglobulins derived from pooled human plasma.
Monoclonal antibodies, designed to target specific components of the immune response, present another avenue for intervention. Both IVIG and mABs are being investigated for their potential to restore immune homeostasis.
The current official indications include symptoms present in chronic illness and many post-viral conditions: Myo- and Pericarditis, Small Fiber Neuropathy but also acute/severe conditions like Sepsis.

Find more about IVIG and mABs Therapy here

Oxygène hyperbare / Cryothérapie / Ozone-EBOO

For specific symptoms and subgroups after H.E.L.P. Apheresis treatment these treatments can speed up and enforce the recovery process. (Note: HBOT is only administered after H.E.L.P. Apheresis therapy. Ozone-EBOO is only administered after H.E.L.P. Apheresis and only in special cases) 

Find more information on Hyperbaric Oxygen Treatment here and Cryotherapy here

Thérapie mitochondriale

Mitochondrial therapy, also known as metabolic correction, is an emerging approach in the management of Long Covid and chronic illnesses characterized by fatigue. This therapy aims to enhance mitochondrial function, which is often impaired in these conditions, by providing specific nutrients and cofactors that support cellular energy production. Key substances used in mitochondrial therapy include NAC (N-Acetyl L-Cysteine), L-Serine, L-Carnitine, Nicotinamide Riboside (NR), L-Choline, NT Factor, and NADH. These compounds work synergistically to replenish depleted cellular antioxidants, enhance mitochondrial biogenesis, improve fatty acid metabolism, and restore ATP production, ultimately helping to alleviate fatigue and improve overall cellular health in individuals suffering from prolonged symptoms of Long Covid and other chronic fatigue-related conditions.

Find more about Mitochondrial Therapy here

‘Early Treatment Packages’ – Reinfection Care

Many of our last year’s patients had to come back to us for another course of H.E.L.P. Apheresis and Combination Therapy treatment, because they reinfected with Covid and were thrown back to experiencing Long Covid symptoms. This is why we started giving out ‘Early Treatment packages’ which avoid exactly that. Our prescribing doctors will supply you with everything needed to get through your next reinfection without risking to worsen again. 

Exemple de programme de traitement

Visualisation des options de traitement du protocole de Chypre

In the below PDF you find a visualisation of available treatments (this is solely for the purpose of demonstrating available options – this NOT a real life case/treatment schedule)

Recommandation : Télécharger et zoomer pour plus de détails.

Télécharger le PDF

Sources scientifiques et études sur l'aphérèse thérapeutique pour le traitement des affections de longue durée (Covid/Post Vac) et d'autres affections

Protocole Aphérèse H.E.L.P. 

A collection of sources which have published success rates can be found at the Long Covid Apheresis Community (LCA Community): https://lcacommunity.org/research

Les résultats publiés par la communauté ACV ont été confirmés lors de l'ISFA2023 :

ISFA 2023 (Conférence mondiale de la Société internationale d'aphérèse)

Inusphérèse

Science 2024 – new study looking at the relation between microclots and immune damage in Long Covid:

Quote: ‘…coagulation in Long Covid is indicated by the detection of circulating fibrinolysis-resistant microclots that are enriched in vWF, C7, acute-phase serum amyloid proteins, and fibrin, proteins identified in the proteomics screen by Cervia-Hasler et al. as contributors to Long Covid.’

Full study: https://www.science.org/doi/10.1126/science.adn1077

En termes plus simples, cette étude examine les raisons de la persistance des symptômes chez certaines personnes après avoir guéri de COVID-19, une condition connue sous le nom de Long Covid. Les chercheurs ont constaté que les patients atteints de la maladie de Long Covid ont une activation continue du système immunitaire, en particulier du système du complément, qui entraîne une inflammation et la formation de caillots sanguins. Contrairement à la maladie COVID-19 aiguë, où le foie joue un rôle majeur dans les réponses immunitaires, dans la maladie Long Covid, l'inflammation semble être plus localisée, impliquant les tissus et les cellules immunitaires. L'étude suggère que cette activation immunitaire persistante, en particulier dans le système du complément, contribue aux symptômes ressentis par les patients atteints de la maladie de Long Covid.

Les chercheurs ont identifié des protéines spécifiques, telles que la pentraxine 3 et les composants du complément, qui sont associées au Long Covid. Le système du complément, lorsqu'il n'est pas contrôlé, peut endommager les cellules et les vaisseaux sanguins. Chez les patients atteints de Covidie longue, on observe une activation excessive du complément, qui entraîne une inflammation et la formation de microclot . Cet état inflammatoire permanent, même en l'absence de coagulation sanguine généralisée, peut expliquer les symptômes persistants observés chez les patients atteints de Covidie longue, tels que la fatigue et les problèmes cognitifs.

En outre, l'étude a révélé des déséquilibres dans les facteurs liés à la coagulation du sang, ce qui suggère un mécanisme potentiel de thrombo-inflammation chez le Long Covid. Bien que les raisons exactes de l'activation immunitaire et de la coagulation persistantes chez Long Covid ne soient pas entièrement comprises, l'étude indique que le ciblage de composants spécifiques des systèmes immunitaire et de coagulation pourrait être une voie potentielle de traitement chez Long Covid. 

H.E.L.P. Apheresis and Inuspheresis®  address most if not all of the above. Microclots, Hypercoagulation, Inflammation, Pathogens to list just a few modes of action of H.E.L.P. Apheresis and Inuspheresis® . The rest can be addressed by other elements of the multimodal Combination Therapy of ‘The Cyprus Protocol’.

Vous trouverez de nombreuses informations sur notre blog concernant les différents types d'aphérèse et le type d'aphérèse qui convient le mieux à chaque cas. ICI

Notre centre d'aphérèse et H.E.L.P. Aphérèse à la télévision

ITV News, BBC News, France 2 et WDR TV. Extraits de certains reportages sur notre centre d'aphérèse et H.E.L.P. Aphérèse pour les maladies chroniques, les syndromes post-vaccinaux et les maladies post-longues.

Témoignages

Jeremy Smith, Long Covid, États-Unis

‘I had 4 Help Apheresis treatments last year in Germany. They brought me back to 80% of my former capacity. 

The Apheresis Center is a totally different experience and I am super happy I chose Cyprus. It is very different from Germany. The doctors, nurses and the whole team are doing everything to bring me back to my full capacity, their knowledge about Long Covid and the individually adapted treatment is great – a real concierge medicine experience! I missed home last year in Germany – here in Cyprus not a single day, we even extended our stay and will come back next year for holidays!’

You can read and watch Jeremy’s full story here: Full Video

Katrina Krulla, Long Covid, États-Unis

‘I have had some amazing results with H.E.L.P. Apheresis for my Long Covid – my 6th treatment got me back to feeling 75% to 90% recovered. Larnaca was truly an amazing place for recovery. Also the great community for support that formed with others getting treatment was so wonderful. It was so nice to have a team of people helping you that “got it” and believed you in addition to being with others suffering the same life changing illness.’

Patricia Price, ME/CFS, Royaume-Uni

Patricia souffre d'un grave syndrome de la maladie de Creutzfeldt-Jakob (MECFS) depuis 2015 :

‘My Help Apheresis treatment improved my ME by 80%. Help Apheresis took me from being mostly bed bound 23 hours a day – I could not be upright without my heart jumping to 170 beats per minute, even higher if I tried to have a shower – to being able to be upright and be mobile almost every day. It changed my life! I can now manage my own life again. I can go outside again and I was able to gain weight and can now eat three solid meals a day again!

You can watch Patricia’s full story here: Full Video

Landen Williams, Long Covid, États-Unis

Landen luttait contre la respiration, l'anxiété, le brouillard cérébral et d'autres symptômes avant que nous ne le traitions avec H.E.L.P. Apheresis. Plusieurs mois après le traitement, il a retrouvé 70 % de son état antérieur, une certaine fatigue et la PEM sont les derniers symptômes qui persistent partiellement. Il les traite avec une thérapie combinée. La vidéo ci-dessus est une version courte/un extrait de son apparition sur 1819 News (Source : 1819news).

Combination Therapy and H.E.L.P. Apheresis do not achieve the same results in the same time frame for different patients. From our clinical experience we have seen similar success rates as presented on the ISFA 2023 (World Conference of the International Society for Apheresis) – 80% success rate with results varying from smaller improvements to being fully curative. The majority of patients saw a significant improvement. Long Covid, Post Vac and CI are umbrella terms with different subsets – no patient presents the exact same symptoms set.

The time frame in which patients see results also vastly differs – from first treatment to several months. 

Documentaire d'ARTE TV "Long Covid - Guérir à Chypre".

Documentaire d'ARTE TV 'Long Covid - Healing in Cyprus' sur notre centre d'aphérèse

Le documentaire a été diffusé en juin 2024. Une équipe de journalistes de la chaîne de télévision européenne ARTE TV a accompagné trois de nos patients atteints de Long Covid et de Post Vac Syndrom et les a interviewés, ainsi que notre équipe au Centre d'aphérèse. Vous pouvez regarder ici un extrait du documentaire qui est également facile à regarder pour les patients souffrant de dysfonctionnement cognitif, de brainfog et de migraines associées. Audio en anglais par Dubly.

Depuis le tournage du documentaire, de nouvelles découvertes scientifiques ont été faites. Vous pouvez trouver les dernières études publiées ici. 

Markus a publié un billet de blog icioù il décrit les développements et les mises à jour depuis le tournage du documentaire.

Cliquez pour regarder ici